Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Urea | activates at 1 M | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient expression in HeLa cells, in HepG2 cells, in RFL6 cells, and in COS-1 cells, highest expression level is obtained in HeLa cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | plasma | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
von Willebrand factor + H2O | Homo sapiens | large multimeric substrate, cleavage of the peptide bond Tyr842-Met843 within the A2 domain | 2 peptides of 140 kDa and 176 kDa | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | enzym contains 10 potential N-glycosylation sites | Homo sapiens |
proteolytic modification | propeptide is very short and poorly conserved, dispensable for protein folding, is cleaved off by furin after export from the endoplasmic reticulum, the pro-enzyme form is fully active | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | pro-von Willebrand factor is cleaved by pro-ADAMTS13 and by ADAMTS13 | Homo sapiens | ? | - |
? | |
proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
von Willebrand factor + H2O | cleavage of the peptide bond Tyr842-Met843 within the A2 domain | Homo sapiens | 2 peptides of 140 kDa and 176 kDa | - |
? | |
von Willebrand factor + H2O | large multimeric substrate, cleavage of the peptide bond Tyr842-Met843 within the A2 domain | Homo sapiens | 2 peptides of 140 kDa and 176 kDa | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | i.e. a disintegrin and metalloprotease with thrombospondin repeats | Homo sapiens |
M12.241 | Merops-ID | Homo sapiens |
von-Willebrand factor cleaving protease | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
room temperature, assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |